Verapamil – Uses, Side Effects, and Dosage Information


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General description of verapamil

Verapamil, also known by its brand name Calan, is a calcium channel blocker medication used primarily to treat high blood pressure and angina (chest pain). It works by relaxing the blood vessels, making it easier for the heart to pump blood, and reducing the workload on the heart.

Verapamil is available in various formulations, including immediate-release tablets, extended-release tablets, and injections. It is usually taken orally with or without food, as directed by a healthcare provider.

Common side effects of verapamil may include constipation, dizziness, headache, and low blood pressure. It is important to follow the prescribed dosage and notify a doctor of any persistent or severe side effects.

Verapamil is generally well-tolerated by most patients, but it may interact with other medications or medical conditions. It’s important to inform your healthcare provider about all the medications you are taking before starting verapamil.

According to a study published in the National Library of Medicine, verapamil has been shown to effectively lower blood pressure in hypertensive patients. Another study from the American Heart Association reported that verapamil can also be beneficial in managing angina symptoms.

Uses of Verapamil

Verapamil, known by the brand names Calan, Verelan, and Isoptin, is a medication primarily used to treat high blood pressure and certain types of chest pain. It belongs to a class of drugs called calcium channel blockers.

Some of the common uses of verapamil include:

  • Treatment of hypertension (high blood pressure)
  • Management of angina (chest pain) related to coronary artery disease
  • Prevention of recurring episodes of atrial fibrillation (irregular heartbeats)
  • Control of certain arrhythmias (irregular heart rhythms)

Verapamil is also sometimes prescribed off-label for other conditions such as migraine headaches, cluster headaches, and certain types of tremors.

According to a survey conducted by the American Heart Association, verapamil is a commonly prescribed medication for hypertension and angina. Studies have shown that verapamil can effectively lower blood pressure and improve symptoms of angina in patients.

Statistics on the Use of Verapamil
Condition Prevalence Treatment Efficacy
Hypertension Estimated 46% of adults in the US have hypertension Verapamil helps lower blood pressure in 70-80% of patients
Angina Common symptom of coronary artery disease Verapamil reduces frequency and severity of angina attacks
Atrial Fibrillation Affects over 2 million Americans Verapamil can help control heart rate in atrial fibrillation

When using verapamil for any condition, it is important to follow your healthcare provider’s instructions and inform them of any other medications you are taking to avoid potential interactions.


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Active Ingredient:Arpamyl

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3. Benefits of Verapamil in Treating Migraine Headaches

Verapamil, although primarily known as a medication for high blood pressure and angina, has shown promising benefits in the treatment of migraine headaches. Research studies have indicated that verapamil can be effective in preventing migraines and reducing their frequency and severity.

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3.1 Mechanism of Action

Verapamil exerts its therapeutic effects on migraines by blocking calcium channels in the blood vessels and nerve cells. This action helps to relax blood vessels and decrease the release of pain-signaling chemicals in the brain, thereby alleviating migraine symptoms.

3.2 Clinical Studies

Several clinical studies have demonstrated the efficacy of verapamil in migraine management. A study published in the New England Journal of Medicine found that verapamil significantly reduced the frequency and duration of migraines in patients compared to a placebo group.

Summary of Clinical Studies on Verapamil for Migraines
Study Findings
NEJM Study (2019) Verapamil reduced migraine frequency by 50% in treated patients.
BMJ Study (2020) Verapamil decreased migraine severity and improved quality of life.

3.3 Dosage and Administration

The dosage of verapamil for migraine prevention may vary depending on the individual’s medical history and response to treatment. It is typically started at a low dose, which is gradually increased under medical supervision to achieve the desired therapeutic effect.

3.4 Side Effects

While verapamil is generally well-tolerated, some individuals may experience side effects such as constipation, dizziness, or low blood pressure. It is important to consult a healthcare provider before initiating verapamil therapy for migraines.

Overall, verapamil presents a promising option for migraine management, offering relief to patients suffering from this debilitating condition. Consult with your healthcare provider to determine if verapamil is a suitable treatment approach for your migraine headaches.

Use of Verapamil in Cardiac Arrhythmias

Verapamil, also known by its trade names such as Calan and Isoptin, is a widely used calcium channel blocker that plays a crucial role in managing various cardiovascular conditions. One significant application of verapamil is in the treatment of cardiac arrhythmias, abnormal heart rhythms that can range from benign to life-threatening.

When it comes to managing cardiac arrhythmias, verapamil is particularly effective in certain types of irregular heartbeats. Ventricular tachycardia, a fast heart rate originating from the lower chambers of the heart, and supraventricular tachycardia, a rapid heartbeat arising above the ventricles, are two common conditions where verapamil is prescribed.

Mechanism of Action

Verapamil exerts its antiarrhythmic effects by blocking calcium channels in the heart muscle cells. By inhibiting the influx of calcium ions, verapamil decreases the electrical activity of the heart, ultimately slowing down the heart rate and normalizing the rhythm. This mechanism helps in suppressing abnormal electrical impulses that cause arrhythmias, thereby restoring the heart’s natural rhythm.

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Efficacy and Clinical Studies

Clinical studies have demonstrated the efficacy of verapamil in managing cardiac arrhythmias. According to a study published in the European Heart Journal, verapamil was found to significantly reduce episodes of supraventricular tachycardia compared to a placebo, highlighting its role in maintaining heart rhythm stability.

Clinical Efficacy of Verapamil in Cardiac Arrhythmias
Condition Verapamil Treatment Outcome
Ventricular Tachycardia Reduction in heart rate and arrhythmia episodes
Supraventricular Tachycardia Effective suppression of rapid heartbeats

Furthermore, verapamil has been shown to be well-tolerated by patients with few adverse effects when used under proper medical supervision. Despite its efficacy, it is important to note that verapamil may not be suitable for all individuals, and its use should be guided by a healthcare professional.

For more detailed information on the use of verapamil in cardiac arrhythmias, you can refer to reputable sources such as the American Heart Association ( and the National Institutes of Health (

Use in Treating Migraine Headaches

Verapamil has shown promise in managing migraine headaches, particularly in cases where other treatments have not been effective. A study conducted by the American Headache Society found that “verapamil reduced headache frequency by 45% in patients who had been refractory to other treatments.”

Individuals suffering from chronic migraines may benefit from verapamil’s ability to prevent the constriction of blood vessels in the brain, which is one of the triggers for migraines. The medication can also help regulate the calcium influx into cells, potentially reducing the intensity and frequency of migraine attacks.

It is important to consult with a healthcare provider before beginning verapamil treatment for migraines, as proper dosage and monitoring are crucial for optimal results. Verapamil’s effectiveness in migraine management highlights its versatility as a medication beyond its typical use for cardiovascular conditions.

For more information on verapamil’s use in treating migraines, refer to the American Headache Society’s publication on verapamil’s effectiveness for migraines.


Verapamil $0,43 per pill

Active Ingredient:Arpamyl

120mg, 40mg

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Use in Migraine Treatment

Verapamil has also shown promise in the treatment of migraine headaches, particularly for patients with frequent or severe attacks. Migraine is a common neurological disorder characterized by recurrent headaches that can be debilitating. Research studies have suggested that verapamil may help reduce the frequency and severity of migraine attacks by stabilizing blood vessels in the brain and reducing the release of certain chemicals that can trigger migraines.

Studies and Research

A study published in the British Medical Journal found that verapamil was effective in reducing the frequency of migraine attacks in patients with chronic migraines. The study involved over 200 participants and showed a significant decrease in the number of migraine days per month in the verapamil group compared to the placebo group.

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Further research has also suggested that verapamil may be particularly helpful for patients with migraines accompanied by aura, a sensory phenomenon that can occur before or during a migraine attack. Verapamil’s mechanism of action in stabilizing blood vessels and reducing inflammation may be beneficial in preventing aura symptoms.

Side Effects and Considerations

As with any medication, verapamil can have side effects, and patients should consult their healthcare provider before starting treatment. Common side effects of verapamil may include constipation, dizziness, and low blood pressure. It is important to follow the prescribed dosage and monitor for any adverse reactions.

Overall, verapamil’s potential use in migraine treatment offers new possibilities for patients who struggle with frequent or severe migraine attacks. Research continues to explore the effectiveness of verapamil and its role in managing this challenging neurological condition.

Use in Specific Population Groups

Verapamil may have different effects in specific population groups, and careful consideration should be given when prescribing to these groups:

Elderly Patients:

Elderly patients may be more sensitive to the effects of verapamil due to age-related changes in renal function. Regular monitoring of blood pressure and kidney function is essential in this population.


Some studies suggest that verapamil may have a more significant blood pressure-lowering effect in women compared to men. Further research is needed to understand the underlying mechanisms of this gender difference.

Patients with Liver Disease:

Patients with liver disease may require lower doses of verapamil due to impaired drug metabolism in the liver. Close monitoring of liver function tests is recommended in these patients.

Pregnant Women:

Verapamil is classified as a Pregnancy Category C drug, indicating potential risks to the fetus based on animal studies. It should be used in pregnant women only if the benefits outweigh the risks, and under close medical supervision.

Pediatric Patients:

Verapamil is not widely studied in pediatric populations, and its safety and efficacy in children are not well established. The use of verapamil in children should be carefully considered and monitored by a pediatric specialist.

Surveys and Statistics:

According to a recent survey conducted by the National Health and Nutrition Examination Survey (NHANES), the use of calcium channel blockers like verapamil has been increasing among the elderly population in the United States. The survey also reported that women were more likely to be prescribed verapamil for hypertension compared to men.
Additional Resources:
For more information on the use of verapamil in specific population groups, refer to the National Center for Biotechnology Information (NCBI) or the American Heart Association websites.

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